Discuss the process towards the discovery of TNF as a molecule of major importance, and proof that its inhibition may be of benefit to rheumatoid arthritis patients,

Present the evidence for the proof of concept and validation of a drug target for a biologic, in this case this will be (infliximab), the pathfinding biologic that has revolutionised the treatment of rheumatoid arthritis.

Discuss the process towards the discovery of TNF as a molecule of major importance, and proof that its inhibition may be of benefit to rheumatoid arthritis patients, to the first clinical trial, and then the phase-ll trial that finally proved the clinical efficacy.