How can we make servicemembers more resilient to Combat Stress (e.g., Post-Traumatic Stress Disorder (PTSD))? How can we measure, use, or manipulate the production of Neuropeptide-Y (synthetic or natural) to increase resiliency in Servicemembers, in hopes of mitigating PTSD entirely? What are the current treatment modalities (Cognitive Behavioral Therapy, Psychotropics, Stellate Ganglion Block, Anti-depressants, etc.) for PTSD?

Systematic literarture review

Method: Utilizing PICOS (population/problem/phenomenon, intervention, comparison, outcome, study design) to guide articles to use.

Question: How can we make servicemembers more resilient to Combat Stress (e.g., Post-Traumatic Stress Disorder (PTSD))? How can we measure, use, or manipulate the production of Neuropeptide-Y (synthetic or natural) to increase resiliency in Service members, in hopes of mitigating PTSD entirely? What are the current treatment modalities (Cognitive Behavioral Therapy, Psychotropics, Stellate Ganglion Block, Anti-depressants, etc.) for PTSD? Is there any evidence to suggest that increasing Neuropeptide-Y via stress innoculation/realistic training or synthetic injection, could increase resiliency to trauma or prevent PTSD symptoms? Is effective in reducing PTSD symptoms?

Population: Adult patients, Military, PTSD

(Current) Interventions: Synthetic or naturally secreted Neuropeptide-Y

Comparison: Current standard treatment. For example,
Cognitive Behavioral therapy, Stellate Ganglion Block, Anti-Depressants, Psychotherapy, Pain management.

Outcome: Alternative Treatment modality for PTSD or a pathway to increase resiliency to PTSD in Service Members.

References: Less than 8 years old