What is antibiotic resistance-When was antibiotic resistance discovered?

Antibiotic Resistance

There are 5 main points would like to be included in the paper:

1. History and application

a. Definition of antibiotics and uses
b. Who and when antibiotics was invented
c. Mechanisms of antibiotics
d. Example of antibiotic that treat a specific disease

2. Antibiotic Resistance

a. What is antibiotic resistance ?
b. When was antibiotic resistance discovered?
c. How does antibiotic resistance happen? (Causes)
d. Acquired resistance Vs. Natural resistance
b. Examples of superbugs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/

3. Mechanisms of resistance

a. limiting uptake of a drug
b. modifying a drug target
c. inactivating a drug
d. active drug efflux.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604941/#:~:text=The%20main%20mechanisms%20of%20resistance,or%20acquired%20from%20other%20microorganisms.

4. How does antibiotic resistance spread?

5. Strategies to Combat Antimicrobial Resistance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149102/

Please use figures or graphs where applicable