Comment on the three discussion posts below (1 paragraph for each, support your response with a rationale, and cite the source)
DISCUSSION 1
A 30 year old woman recently diagnosed with rheumatoid arthritis (RA), complains of general fatigue and weight loss along with symmetric joint welling, stiffness, and pain. The stiffness is more prominent in the morning and subsides during teh day. Laboratory measures reveal an RF of 120 IU/ml (nonreactive, 0 to39 IU/mL; weakly reactive, 40 to 79 IU/ml; reactive, > 80 IU/ml).
Describe the immunopathogenesis of the joint changes that occur in RA.
What is the significance of her RF test results?
How do her complaints of general fatigue and weight loss related to the RA disease process
DISCUSSION 2
A 38 year old female with a past medical history of significant for lupus erythematosus (SLE) and hypertension, presents to her Primary Care Physician (PCP) for a wellness visit. On physical exam, she is in no distress, VS BP 160/80mmHg (normal takes metoprolol and lisinopril but forgets from time to time) HR 80bpm RR 20/min.
Q1: Compare the etiology of Acute and Chronic Kidney Disease.
Q2: Describe the mechanism for Acute Kidney Injury in Acute Tubular Necrosis.
Q3: Identify nephrotoxic agents and discuss how they affect renal function.
DISCUSSION 3
A 38 year old female with a past medical history of significant for lupus erythematosus (SLE) and hypertension, presents to her Primary Care Physician (PCP) for a wellness visit. On physical exam, she is in no distress, VS BP 160/80mmHg (normal takes metoprolol and lisinopril but forgets from time to time) HR 80bpm RR 20/min.
Q1: Compare the etiology of Acute and Chronic Kidney Disease?
Q2: Describe the mechanism for Acute Kidney Injury in Acute Tubular Necrosis.
Q3: Identify nephrotoxic agents and discuss how they affect renal function.