Describe a protocol for simulating a large heterogeneous DNA nanopore/membrane system, and discuss the structural features of the nanopore that could be characterised at different stages of the simulation protocol. Make use of figures provided in the Supplementary Information as you deem appropriate.

SECTION A Molecules based on the motif in Figure 1A(See Supplementary Information), are referred to as “Hamilton clefts” (HC).They have been found to bind to barbiturates and related molecules, labelled B1 to B7, in solution(See Supplementary Information, Figure 1B). The concentration of the bound HC-Bncomplex can be determined as can the relative strength of the […]